Emmanuel Zorn, PhD

Profile Headshot

Overview

Dr. Zorn is an Associate Professor of Medical Sciences at Columbia University Medical Center in New York City. Dr. Zorn received a Ph.D. in tumor immunology from Paris University in 1999 for his studies on melanoma antigens targeted by tumor infiltrating T cells. He then joined Dana-Farber Cancer Institute where he studied the role of regulatory T cells in chronic graft versus host disease in humans. Dr. Zorn moved to the Transplant Center at Massachusetts General Hospital in 2006 to work on human kidney graft rejection. He then relocated to Columbia University Medical Center in 2014, where he directs a human transplantation immunology research laboratory. He is also the Director of the Columbia Center for Translational Immunology Biobank core. The primary focus of Dr. Zorn’s lab is on B cells and antibodies in mechanisms of rejection or acceptance of kidney and heart transplants.

Lab Projects

Role of B cells infiltrating heart transplants during cardiac allografts vasculopathy: B cell infiltrates are often observed in solid organ grafts during chronic and acute rejection, yet their function is still unclear. Our studies use cardiac al grafts explanted because of rejection to isolate infiltrating B cells and determine their contribution to the rejection mechanism.

Role of Natural Antibodies in solid organ graft rejection: Natural antibodies are broadly reactive serum immunoglobulins implicated in apoptotic cell clearance. Their contribution to inflammatory reactions associated with graft tissue destruction has not been examined. We initiated a large multi-center study using samples collected from kidney transplant recipients at our institution as well as at collaborating centers in the USA, Canada and Europe to investigate the clinical significance of natural antibodies in transplant rejection. We also investigate the function of these natural antibodies in in mechanisms of acute and chronic graft rejection.

We have recently reported the presence of antibody-secreting plasma cells in the human thymus. These cells accumulate with age in the thymic perivascular space and include clones with specificity to common viruses. Ongoing studies in our lab are investigating the role of these plasma cells in anti-viral protection as well as T cell negative selection.

Academic Appointments

  • Associate Professor of Medical Sciences (in Medicine)

Administrative Titles

  • Director CCTI Biobank

Languages

  • French

Credentials & Experience

Education & Training

  • PhD, 1999 Immunology, University of Paris, France

Research

Dr. Zorn is a Professor of Medical Sciences at Columbia University Medical Center in New York City. Dr. Zorn received a Ph.D. in tumor immunology from Paris University in 1999 for his studies on melanoma antigens targeted by tumor infiltrating T cells. He then joined Dana-Farber Cancer Institute where he studied the role of regulatory T cells as well as combined antibody and T cell responses to minor histocompatibility antigens in human chronic graft versus host disease. Dr. Zorn moved to the Transplant Center at Massachusetts General Hospital in 2006 to work on human kidney graft rejection. He then relocated to Columbia University Medical Center in 2014, where he directs a human transplantation immunology research laboratory. He is also the Director of the Columbia Center for Translational Immunology Biobank and specimen processing core.

Selected Publications

Selected Recent Publications 

 

  1. See SB, Yang X, Burger C, Lamarthée B, Snanoudj R, Shihab R, Tsapepas DS, Roy P, Larivière-Beaudoin S, HamelinK, Mendoza Rojas A, van Besouw NM, Bartosic A, Daniel N, Vasilescu ER, Mohan S, Cohen D, Ratner L, Baan CC, Bromberg JS, Cardinal H, Anglicheau D, Sun Y, Zorn E. Natural antibodies are associated with rejection and long-term renal allograft loss in a multi-center international cohort. Transplantation. 2022; In press

 

  1. Mantell  BS, Cordero  H, See  SB, Clerkin  KJ, Vasilescu  R, Marboe  CC, Naka  Y, Restaino  S, Colombo  PC, Addonizio  LJ, Farr  MA, Zorn  E. Transcriptomic heterogeneity of antibody mediated rejection after heart transplant with or without donor specific antibodies.J Heart Lung Transplant. 2021. 40(11): 1472-1480.

 

  1. Cordero H, King RG, Dogra P, Dufeu C, See SB, Chong AM, Uhlemann AC, Ho SH, Kalfa DM, Bacha EA, Kearney JF, Zorn E. Intrathymic differentiation of natural antibody-producing plasma cells in human neonates. Nature Communications. 2021. 12: 5761

 

  1. Melms JC, Biermann J, HuangH, Wang Y, Nair A, Tagore S, Katsyv I, Rendeiro AF, Amin AD, Schapiro D, Frangieh CJ, Luoma AM, Filliol A, FangY, Ravichandran H, Clausi MG, Alba GA, Rogava M,. Chen SW, Ho P, Montoro D, Guo X, Kornberg AE, Han AS, Bakhoum M, Anandasabapathy N, Suarez-Farinas M, Bakhoum SF, Lefkowitch JH, Marboe C, Lagana SM, Del Portillo A, Zorn E, Markowitz GS, Schwabe RF, Schwartz RE, Elemento O, Saqi A, Hibshoosh H, Que J, Izar B. A single-cell lung atlas of lethal COVID-19. Nature 2021. 595:114-119.

 

  1. Yun TJ, Igarashi S, Zhao H, Perez OA, Pereira MR, Zorn E, Shen Y, Goodrum F, Rahman A, Sims PA, Farber DL and Reizis B. Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells. Science Immunology. 2021. Apr 2; 6(58)

 

  1. Habal MV, Miller AM, Rao S, Lin S, Obradovic A, Khosravi-Maharlooei M, See SB, Roy P, Shihab R, Ho SH, Marboe C, Naka Y, Takeda K, Restaino S, Han A, Mancini D, Givertz M, Madsen JC, Sykes M, Addonizio L, Zorn E. T cell repertoire analysis suggest a prominent bystander response in human cardiac allograft vasculopathy. American J. Transplant. 2020. 21: 1465-1476.

 

  1. Hidalgo Y, Nuñez S, Fuenzalida MJ, Flores-Santibáñez F, PJ Saez, Dorner J, Lennon-Dumenil AM, Martínez V, Zorn E, Rosemblatt M, Sauma D, Bono MR. Thymic B cells promote germinal center-like structures and the expansion of follicular helper T cells in lupus-prone mice. Frontiers in Immunology. 2020. 11:696

 

  1. See SB, Mantell BS, Clerkin KJ, Ray B, Vasilescu ER, Marboe CC, Naka Y, Restaino S, Colombo PC, Addonizio LJ, Farr MA, Zorn E. Profiling non-HLA antibody responses in antibody-mediated rejection following heart transplantation. American J. Transplant. 2020. 20:2571-2580.

 

  1. Moore C, Gao B, Roskin KM, Vasilescu R, Addonizio L, Givertz MM, Madsen JC, Zorn E. B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy. American J. Transplant. 2020. 20:1431-1438.

 

  1. Delville M, Lamarthée B, Pagie S, See SB, Rabant M, Burger C, Gatault P, Giral M, Thaunat O, Arzouk N, Hertig A, Hazzan M, Matignon M, Mariat C, Caillard S, Kamar N, Sayegh J, Westeel PF, Garrouste C, Ladrière M, Vuiblet V, Rivalan J, Merville P, Bertrand D, Le Moine A, Van Huyen JPD, Cesbron A, Cagnard N, Alibeu O, Satchell SC, Legendre C, Zorn E, Taupin JL, Charreau B, Anglicheau D. Early acute microvascular kidney transplant rejection in the absence of anti-HLA antibodies is associated with performed IgG antibodies against diverse glomerular endothelial cell antigens. J. Am. Soc. Nephrol. 2019. 30: 692-709.

 

  1. See SB Aubert O, Loupy A, Veras Y, Lebreton X, Gao B, Legendre C, Anglicheau D, Zorn E. Post-Transplant Natural Antibodies Associate with Kidney Allograft Injury and Reduced Long-Term Survival. J. Am. Soc. Nephrol. 2018. 29: 1761-1770.

 

  1. Chatterjee D, Moore, C, Gao B, Clerkin KJ, See SB, Shaked D, Rogers K, Nunez S, Veras Y, Addonizio L, Givertz MM, Naka Y, Mancini D, Vasilescu R, Marboe C, Restaino S, Madsen JC, Zorn E. Prevalence of polyreactive innate clones among graft infiltrating B cells in human cardiac allograft vasculopathy. J Heart Lung Transplant. 2018. 37(3):385-393. 

 

  1. Kennel PJ, Saha A, Maldonado DA, Givens R, Brunjes DL, Castillero E, Zhang X, Ji R, Yahi A, George I, Mancini DM, Koller A, Fine B, Zorn E, Colombo PC, Tatonetti N, Chen EI, Schulze P. Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection. C. J Heart Lung Transplant. 2018. 37(3):409-417.

 

  1. Clerkin KJ, See SB, Farr MA, Restaino SW, Serban G, Farhana Latif F, Li L, Colombo PC, Vlad G, Ray Bryan, Vasilescu ER and Zorn E. Comparative assessment of anti-HLA antibodies using 2 commercially available Luminex-based assays. Transplantation Direct. 2017. Oct 2;3(11):e218.

 

  1. Gao B, Gu Y, Rong C, Moore C, Porcheray F, Wong W, Preffer F, Saidman SL, Fu Y, Cosimi AB, Sachs DH, Kawai T, Sykes M, Zorn E. Dynamics of B cell recovery following kidney/bone marrow transplant recipients.  Transplantation. 2017; 101: 2722-2730.

 

  1. See SB, Clerkin KJ, Kennel PJ, Zhang F, Weber MP, Rogers K, Chatterjee D, Vasilescu ER, Vlad G, Naka Y, Restaino S, Farr M, Topkara VK, Colombo PC, Mancini DM,  Schulze PC, Levin B, Zorn E.  Ventricular assist device elicits serum natural IgG that correlate with the development of primary graft dysfunction following heart transplantation. J Heart Lung Transplant. 2017. 36: 862-870.

 

  1. Sprangers B, DeWolf S, Savage T, Morokata T, Obradovic A, LoCascio S, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer F, Olek S, Dombkowski D, Turka L, Colvin R, Winchester R, Kawai T, Sykes M. Origin of enriched regulatory T cells in patients receiving combined kidney/bone marrow transplantation to induce transplantation tolerance. American J. Transplant. 2017. 17: 2020-2032.

 

  1. Clerkin KJ, Farr MA, Restaino SW, Zorn E, Latif F, Vasilescu ER, Marboe CC, Colombo PC, Mancini DM. Donor-specific anti-HLA antibodies with antibody-mediated rejection and long-term outcomes following heart transplantation. J Heart Lung Transplant. 2017. 35(5):540-545.

 

  1. Nuñez S, Moore C, Gao B, Rogers K, Hidalgo Y, del Nido P, Restaino S, Naka Y, Bhagat G, Madsen JC, Bono MR and Zorn E. The human thymus perivascular space is a functional niche for viral-specific plasma cells. Science Immunology. 2016. Dec; 1(6) eaah4447

 

For a complete list of publications, please visit PubMed.gov(link is external and opens in a new window)