Bauer Lab

Location and Contact Information

630 W.168th Street
PS10-401
New York, NY 10032
United States

212-342-0952

Principal Investigators

The Bauer Lab uses a mix of molecular biology, animal physiology, and functional genomics to translate human genetics studies into actionable biological mechanisms, with a specific focus on cardiometabolic traits. Current work in the lab includes continued research into the roles of Tribbles-1 in regulating plasma lipid metabolism in extrahepatic tissues, exploring the role of TRIB1 in non-alcoholic fatty liver disease, development of novel therapeutics targeting Tribbles-1 activity, and understanding the effects of common DNA variation on nearby gene expression through functional genomics (i.e. ATAC-Seq, CRISPR/Cas9 screen, etc). We have a strong interest in training the next generation of cardiometabolic translational scientists, and potential students and trainees are encouraged to reach out for potential opportunities to work in the lab.

 

Lab Members

  • Elizabeth Ha

    Graduate Student

    Education and Training

    BS, Stony Brook University

    I am interested in gaining experience in experimental design and hypothesis formation, and in learning laboratory techniques as well as bioinformatics analysis. I hope to accomplish these goals as I study the role of the Tribbles1 pseudokinase in adipose tissue and how it affects plasma lipid levels, and as I interrogate the Trib1 genomic locus for functional regions using high-throughput methods.

    Elizabeth Ha
  • Kavita Jadhav

    Postdoctoral Research Scientist

    Education and Training

    BSc Biotechnology, Ferguson College (2008)

    Msc Dietetics, Pune University (2010)

    MS Nutrition, SUNY Buffalo (2012)

    PhD Cell and Molecular Biology, Kent State University (2017)

    I recently completed my doctoral studies at Kent State University and am officially the first post-doc of the Bauer Lab! As a graduate student my research focused on investigating the role of transcription factors and bile acid receptors in the development of non-alcoholic fatty liver disease (NAFLD). In the same vein, my current interests include investigating the role of hepatic Tribbles1 and CCAAT-enhancer binding protein alpha (C/EBP-α) in the pathophysiology of non-alcoholic steatohepatitis (NASH). Likes: Western blots, animal studies, books, coffee, cats, wandering the streets of NYC. Dislikes: Pull-down assays, genotyping, e-readers, smelly subways.

  • Noel Walsh

    Research Technician

    Education and Training

    2016, BSc in Biotechnology - Dublin City University, Ireland

    I received my Bachelors in Biotechnology at Dublin City University in 2016. My undergraduate research involved expression of the myosin protein, MYH10, in adventitial stem cells with relevance to arteriosclerosis/atherosclerosis. After coming to the US, I got my start in research in Dr. Dalton's oncology laboratory at Johns Hopkins University focusing on downstream effects of the SF3B1 spliceosome mutation. I joined the Bauer Lab with the aim of learning new techniques and skills which will prepare me for further graduate studies.

     

Former Members

  • Gabriella Quartuccia

    Doctoral Student in Biology at Binghamton University

    Education and Training

    BS, 2016, University at Buffalo, the State University of New York, Buffalo, NY

    Dr. Bauer’s former Laboratory Manager and Research Technician. I received my BS in Biology from the University at Buffalo where I concentrated my studies in ecology and evolutionary biology. My undergraduate research there involved looking at the evolution of brown, black, and polar bears in the Arctic throughout time using computer modeling. I am presently attending SUNY Binghampton to pursue my PhD in evolutionary genetics and biology. I particularly want to aid in identifying genetic variations that differ between closely related species and elucidating the functional advantage these variants may confer.

    Gabriella Quartuccia

Select Publications

  • Bauer RC, Khetarpal SA, Hand NJ, Rader DJ. Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics. Trends in Molecular Medicine. Elsevier Ltd; 2016 Apr 1;22(4):328–40.

  • Nurnberg ST, Zhang H, Hand NJ, Bauer RC, Saleheen D, Reilly MP, et al. From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circulation Research. Lippincott Williams & Wilkins; 2016 Feb 19;118(4):586–606.

  • Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, et al. Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα. J Clin Invest. 2015 Oct 1;125(10):3809–18.

  • Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, et al. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation. 2015 Mar 31;131(13):1202–13.

  • Bauer RC, Stylianou IM, Rader DJ. Functional validation of new pathways in lipoprotein metabolism identified by human genetics. Curr Opin Lipidol. 2011 Apr;22(2):123–8.