Robert C. Bauer, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine)

Dr. Robert C. Bauer attended Columbia University for his undergraduate studies in Biological Sciences, during which time he worked at Columbia University Medical Center studying the genetics of rare forms of inherited alopecia. Afterwards, he returned to Philadelphia to pursue a PhD in Genetics and Gene Regulation from the University of Pennsylvania, where his doctoral research centered on genetic modifiers of the pediatric liver disorder Alagille Syndrome. For his postdoctoral fellowship, Dr. Bauer remained at the University of Pennsylvania to perform functional validation of novel genes implicated by human genetics in the regulation of plasma lipids, atherosclerosis, and cardiovascular disease. Through this work, Dr. Bauer elucidated the molecular mechanism through which the pseudokinase Tribbles-1 regulates hepatic lipid production and steatosis while also influencing plasma cholesterol and triglyceride levels. Dr. Bauer also published the first in vivo validation of a role for the metalloprotease ADAMTS7 in the development of atherosclerosis, showing that ADAMTS7 activity promotes atherogenesis in mice, which in turn informs therapeutic strategies for targeting this novel gene.

Dr. Bauer can be reached at rcb36@columbia.edu.

Gender

  • Male

Credentials & Experience

Education & Training

  • BA, 2003 Biology, Columbia University
  • PhD, 2010 Genetics and Gene Regulation, University of Pennsylvania School of Medicine

Research

The Bauer Lab uses a mix of molecular biology, animal physiology, and functional genomics to translate human genetics studies into actionable biological mechanisms, with a specific focus on cardiometabolic traits. Current work in the lab includes continued research into the roles of Tribbles-1 in regulating plasma lipid metabolism in extrahepatic tissues, exploring the role of TRIB1 in non-alcoholic fatty liver disease, development of novel therapeutics targeting Tribbles-1 activity, and understanding the effects of common DNA variation on nearby gene expression through functional genomics (i.e. ATAC-Seq, CRISPR/Cas9 screen, etc). We have a strong interest in training the next generation of cardiometabolic translational scientists, and potential students and trainees are encouraged to reach out for potential opportunities to work in the lab.

Grants

REGULATION OF LIPOPROTEIN METABOLISM BY ADIPOSE-SPECIFIC TRIBBLES- (Federal Gov)

Apr 1 2018 - Feb 28 2023

MECHANISMS OF TRIBBLES 1 REGULATION OF LIPOGENESIS AND PLASMA LIPIDS IN HUMANS (Private)

Sep 1 2016 - Jun 30 2019

Selected Publications

  1. Bauer RC, Khetarpal SA, Hand NJ, Rader DJ. Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics. Trends in Molecular Medicine. Elsevier Ltd; 2016 Apr 1;22(4):328–40.
  2. Nurnberg ST, Zhang H, Hand NJ, Bauer RC, Saleheen D, Reilly MP, et al. From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circulation Research. Lippincott Williams & Wilkins; 2016 Feb 19;118(4):586–606.
  3. Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, et al. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation. 2015 Mar 31;131(13):1202–13.
  4. Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, et al. Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα. J Clin Invest. 2015 Oct 1;125(10):3809–18.
  5. Bauer RC, Stylianou IM, Rader DJ. Functional validation of new pathways in lipoprotein metabolism identified by human genetics. Curr Opin Lipidol. 2011 Apr;22(2):123–8.