Clinical Trials

  • Principal Investigator:

    Muredach Reilly, MBBCh, MSCE
    While the biobank can support research of many different diseases and conditions, we are focusing our research now on COVID-19. This research is being conducted to help to advance our understanding of the COVID-19 virus, including but not limited to: how the virus is spread, potential vaccines or other treatments, genetic susceptibility to severe disease, and other questions that will come up as we continue our research studies. CUB will facilitate this research by providing biological samples and medical information to Columbia-NYP researchers and our collaborators around the world who are...
  • Principal Investigator:

    Andrew Jeffrey Einstein, MD, PhD
    We are seeking healthy volunteers and people who have tested positive for COVID-19 in the past. Our study is looking at how coronavirus affects the heart after recovery. If you enroll, you will be given an echocardiogram and a cardiac magnetic resonance imaging (MRI) scan, and you will be asked to provide a blood sample. An echocardiogram is a test that uses sound waves to get a picture of your heart. A cardiac MRI scan uses radio waves to get another kind of picture of your heart. For the MRI, you will receive an injection of a contrast agent, which is safe for qualified participants. There...
  • Principal Investigator:

    Andrew Jeffrey Einstein, MD, PhD
    We are seeking healthy volunteers and people who have tested positive for COVID-19 in the past. Our study is looking at how coronavirus affects the heart after recovery. If you enroll, you will be given an echocardiogram and a cardiac magnetic resonance imaging (MRI) scan, and you will be asked to provide a blood sample. An echocardiogram is a test that uses sound waves to get a picture of your heart. A cardiac MRI scan uses radio waves to get another kind of picture of your heart. For the MRI, you will receive an injection of a contrast agent, which is safe for qualified participants. There...
  • Principal Investigator:

    Tamim M. Nazif, MD
    Are you scheduled for an interventional vascular procedure (e.g. BAV, TAVR/TAVI, EVAR or TEVAR) inorder to replace a damaged or failing valve? This research style studies the safety and efficacy of an Investigational Device (IDE) called the Cross-Seal Suture-Mediated Vascular Closure Device System. This device has not yet been approved by the FDA for use on the market. The device delivers percutaneous sutures (administers stitches through the skin) for the closure of large bores created in the common femoral artery access site during your endovascular aneurysm repair surgery. The objective of...
  • Principal Investigator:

    Mathew S. Maurer, MD
    A drug study looking at the effects of 10 mg Dapagliflozin vs. Placebo in patients with Heart Failure and Preserved Ejection Fraction (HFpEF) with either diabetes or pre-diabetes. Subjects are being asked to take part in this study because they have heart failure (inability of the heart to pump blood with normal efficiency). The purpose of this study is to find out if a drug called dapagliflozin would be effective in improving the blood tests and symptoms related to their heart failure. To do this, dapagliflozin will be compared with placebo. The placebo will look like dapagliflozin but will...
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    The study is designed to to compare the safety and effectiveness of the PASCAL System to the MitraClip System for reduction of degenerative mitral regurgitation.
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    The study is to determine whether aortic valve replacement is helpful for patients who have severe, calcific, aortic stenosis (a narrowing of the aortic heart valve, where calcium has attached to the valve surface, resulting in obstructed blood flow) and do not have symptoms.
  • Principal Investigator:

    Andrew Jeffrey Einstein, MD, PhD
    Phase 3 open-label, multicenter Study of Flurpiridaz Injection for PET Imaging for assessment of Myocardial perfusion in patients referred for Invasive Coronary Angiography because of suspected Coronary Artery Disease
  • Principal Investigator:

    Ajay J. Kirtane, MD, SM
    The purpose of this study is to collect data for evaluating VFR (Virtual Flow Reserve) in comparison with standard FFR (Fractional Flow Reserve) when patients undergo a percutaneous coronary intervention (PCI) to treat blockage or narrowing in the heart artery or arteries.
  • Principal Investigator:

    Robert J. Sommer, MD
    This study will evaluate Patent Foramen Ovale (PFO) closure for migraine headache relief using a device called the GORE CARDIOFORM Septal Occluder. A patent foramen ovale (PFO) is a hole in the heart that didn't close the way it should after birth. During fetal development, a small flap-like opening the foramen ovale is normally present in the wall between the right and left upper chambers of the heart (atria). Most patients with a PFO do not have any symptoms. However, the condition may play a role in migraine headaches and it increases the risk of stroke, transient ischemic attack (stroke...

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