Clinical Trials

  • Principal Investigator:

    Marwah Abdalla, MD
    The Center for Behavioral Cardiovascular Health (CBCH) is conducting a research study to examine the impact that sleep hours have on blood pressure (BP) levels during sleep. Two-part screening to determine eligibility for this study involves a) answering questionnaires and b) documenting daily average sleep duration (how long you sleep) over the course of a 2-week period. Participation in the research study involves 1-4 study visits, wearing a Fitbit activity monitoring device for an additional 8-weeks, wearing a blood pressure measurement device and a heart monitoring patch device for 2...
  • Principal Investigator:

    Gabriel Tal Sayer, MD
    The purpose of this trial is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints.
  • Principal Investigator:

    Siqin Ye, MD
    The Center for Behavioral Cardiovascular Health (CBCH) is conducting a research study to examine the relationship between sleep and nighttime blood pressure levels and whether this relationship has something to do with the way our nervous system functions. Participants must speak English or Spanish and be between 25 and 60 years of age. A 5-minute online survey will determine if you qualify. Qualified participants who complete a 3-day study that includes an overnight sleep assessment at the Columbia University Cardiopulmonary Sleep and Ventilation Disorders Center are eligible for a $ 200...
  • Principal Investigator:

    Keith Diaz, PhD
    U.S. Adults spend on average 11 to 12 hours a day in sedentary behavior. Daily sedentary behavior is strongly associated with risk of cardiovascular disease. The purpose of the BREAK II research study is to answer two questions: (1) How frequent should periods of prolonged sedentary time be interrupted? and (2) What is the appropriate duration or length of time of these breaks in sedentary time? If you are 18 years old or older and have no history of chronic diseases, and no physical disability preventing ability to walk and a non-smoker you may be eligible for this study. Participants will...
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    This is a prospective, multicenter, non-randomized, single-arm, open-label clinical study, sponsored by Pi-Cardia. Fifteen (15) patients with symptomatic severe Aortic Stenosis (narrowing of the aortic valve) who are considered operable but are not recommended by the heart team for immediate treatment with surgical or transcatheter aortic valve replacement will be treated with the Leaflex Performer in up to 7 clinical sites. All enrolled patients will be followed up at 30 days and at 3, 6, 9, and 12 months post-procedure.
  • Principal Investigator:

    Michael B Collins, MD
    This is a Prospective, multicenter, randomized, parallel-controlled, open-label two-arm trial with an adaptive design that will randomize about 1252 subjects at approximately 120 US and international centers. The study is looking to see if a device called the Impella device will improve the way the heart works as well as if health is improved as compared to what is currently used for patients with reduced left-sided heart function. Participants will be will be assigned like by the flip of a coin to receive the Impella device, or assigned to receive standard of care treatment. Participants...
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    This is a prospective, single-arm, multi-center, early feasibility study. This research study is for patients who have Tricuspid Regurgitation (TR), a condition that occurs when the three leaflets of the heart's tricuspid valve do not close properly causing blood to leak backward with each heartbeat. Since some of the blood leaks backward, the heart has to pump more blood with each beat to push the same amount of blood forward. The goal of this study is to evaluate the safety and performance of the Evoque system with Optimal Medical Therapy (OMT) compared to OMT alone in the treatment of...
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    This is a research study for patients who have Tricuspid Regurgitation (TR), a condition that occurs when the three leaflets of the heart's tricuspid valve do not close properly causing blood to leak backward with each heartbeat. Since some of the blood leaks backward, the heart has to pump more blood with each beat to push the same amount of blood forward. The goal of this study is to gain early clinical insight into how the Intrepid transcatheter tricuspid valve replacement (TTVR) system device performs. There is a need for alternative and less invasive treatment options to treat this...

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