Isaac George, MD

Cardiac Surgery, Cardiothoracic Surgery, Interventional Cardiology, Surgery, Thoracic and Cardiac Surgery
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Dr. Isaac George, MD joined NewYork Presbyterian/Columbia University Medical Center in the Department of Surgery in July of 2001 as a resident in general surgery following his graduation from Duke University School of Medicine. Prior to receiving his MD, Dr. George completed a B.S. in Mechanical Engineering at Massachusetts Institute of Technology in 1997. Dr. George also completed a fellowship program in cardiothoracic surgery in 2011 as well as a fellowship program in interventional cardiology in 2012. In July, 2012 Dr. George became an Assistant Professor of Surgery and later an Associate Professor of Surgery and Medicine in 2019.

Dr. George is board certified in thoracic (cardiac) surgery. He performs all types of open and reoperative adult cardiac surgery (aortic, mitral and tricuspid valve surgery, aortic aneurysm surgery, coronary bypass grafting, robotic surgery) with a particular interest in complex valvular and aortic disease. He specializes in minimally invasive mitral valve surgery with small incisions and repair of the mitral valve. He annually performs 150-200+ open heart surgeries a year and is the busiest heart surgeon by procedure volume in New York State. He is one of the few physicians in the world trained in both cardiac surgery and interventional cardiology. Dr. George is currently the Surgical Director of the Structural Heart and Valve Center at Columbia University Medical Center. His surgical outcomes remain some of the best in the state despite taking on the highest risk cases (surgical mortality rate per year ~1.5%).

Dr. George is focused on integrating new technology and innovation into his clinical practice. He is trained in the most current and cutting-edge procedures including Transcatheter Valve Replacement (TAVR, TMVR), transcatheter valvular repair (Mitraclip), percutaneous coronary stenting, and aortic stent grafting. He performs almost 800 transcatheter valve procedures a year, in addition to his busy open surgical practice and has personally done almost 6000 TAVR procedures. Because he is trained in multiple disciplines, he is able to combine strategies to create a treatment plan for each individual patient that is both unbiased and personalized. As Primary Investigator of a national TAVR and tricuspid trials and with involvement in numerous other clinical trials, he has extensive clinical research trial experience.

There are numerous new transcatheter trials for aortic stenosis, aortic insufficiency, bicuspid aortic valves, mitral regurgitation, tricuspid regurgitation, and heart failure that Dr. George is involved. Click here for a full list and description of ongoing trials.

Dr. George is involved in both benchtop and clinical research as well. As former director of the cardiac surgery research laboratory, he oversees surgical fellows, post-doctoral students, masters students, and research assistants in both scientific projects and clinical outcomes in cardiac surgery and TAVR. His projects reflect the translational nature of the lab as well as his clinical interests. His clinical practice allows him to be uniquely positioned to advance this research with a clinical endpoint and potential therapeutic intervention as the goal.

Dr. George can be contacted directly at

Watch: Meet Cardiothoracic Surgeon, Dr. Isaac George

Watch: Dr. Isaac George Discusses Advancements in Heart Valve Surgery

Watch: Decision Making in Aortic Valve Disease with Dr. Isaac George

Watch: Dr. George Discusses Stroke Risk and TAVR

Read: Dr. George Talks Hybrid Cardiac Surgery: A Viable Strategy for Select Patients

Read: What To Expect After A Coronary Artery Bypass, According To Dr. George

Dr. George hosts Taking it to Heart, the Columbia Heart Valve team's podcast. In each episode, Dr. George and the Columbia Heart Valve team discuss a new topic related to valvuar disease. Subscribe to Taking It to Heart.

Click here for a full list and description of ongoing trials from Dr. George.

Click here for a complete list of publications from Dr. George.

Watch: Recovery from COVID

Disclosures: Dr. George is a medical consultant for Atricure, MitreMedical, cardioMech, VDyne, Valcare Medical, Durvena.

Areas of Expertise / Conditions Treated

  • Aortic and Mitral Valve Surgery
  • Aortic Aneurysm
  • Aortic Aneurysm Repair
  • Aortic Aneurysm Surgery
  • Aortic Aneurysm With Dissection
  • Aortic Arch Surgery
  • Aortic Disease
  • Aortic Dissection
  • Aortic Stenosis
  • Aortic Stent Grafts
  • Aortic Surgery
  • Aortic Valve Surgery
  • Atrial Fibrillation, Surgical Treatment
  • Bloodless Surgery
  • Coronary Artery and Valvular Disease
  • Coronary Artery Bypass Surgery (Off Pump)
  • Heart Disease
  • Heart Disease and Women
  • Heart Failure
  • Heart Surgery
  • Heart Transplantation
  • Heart Valve Disease
  • Heart Valve Repair
  • Heart Valve Replacement
  • Heart Valve Surgery
  • High Risk Surgery of the Elderly
  • Minimally Invasive Aneurysm Repair
  • Minimally Invasive Heart Surgery
  • Minimally Invasive Valve Repair
  • Mitral/Aortic Valve Replacement
  • Mitral Valve Reconstruction
  • Mitral Valve Repair
  • Mitral Valve Replacement/Repair
  • Mitral Valve Surgery
  • Off Pump Coronary Bypass Surgery
  • Open Heart Surgery
  • Percutaneous Valve Interventions
  • Pericardial Disease
  • Robotic Surgery
  • TAVR (Transcatheter Aortic Valve Replacement)
  • Thoracic Aneurysm Repair
  • Valve Reconstruction/Repair
  • Valve Replacement
  • Valvular Heart Disease

Academic Appointments

  • Associate Professor of Surgery at CUMC

Administrative Titles

  • Surgical Director of the Heart Valve Center at Columbia
  • Surgical Director, Structural Heart Disease, NYP

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Male

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Phone Appointments

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177 Ft. Washington Avenue
New York, NY 10032

Insurance Accepted


  • Aetna Signature Administrators
  • EPO
  • HMO
  • Medicare Managed Care
  • NYP Employee Plan
  • NY Signature
  • POS
  • PPO
  • Student Health

Affinity Health Plan

  • Essential Plan
  • Medicaid Managed Care


  • Medicare Managed Care
  • Special Needs

Amida Care

  • Special Needs


  • EPO
  • Great West (National)
  • HMO
  • POS
  • PPO


  • Medicare Managed Care
  • PPO


  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross/Blue Shield

  • EPO
  • HMO
  • Medicare Managed Care
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care


  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare


  • Railroad
  • Traditional Medicare


  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty

Quality Health Management

  • Quality Health Management


  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO


  • Medicare Managed Care
  • SelectHealth
  • Special Needs


  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Committees, Societies, Councils

  • 2021 - CRT- Abstract Reviewer, Annual Meeting
  • 2021 - AATS-Abstract Reviewer, Annual Meeting, Adult Cardiac
  • 2020 - 21st Century Cardiothoracic Surgical Society, Member
  • 2020 - ACC 2021 – Abstract Reviewer-Interventional and Structural: Non-Aortic Structural Heart Disease
  • 2020 - ACC 2021: Session Co-Chair – Contemporary Aortic Valve Disease Management
  • 2020 - NY Society of Thoracic Surgeons, Secretary, Program Committee
  • 2020 - TCT Challenging Case Abstract Reviewer
  • 2020 - AHA Cardiovascular Surgery and Anesthesia Council Leadership Committee
  • 2020 - AATS Cardiac Education Committee
  • 2020 - Scientific Sessions, American Heart Association Annual Meeting Abstract Reviewer
  • 2020 - EACTS – Annual Meeting Abstract reviewer
  • 2020 - STS COVID-19 Task Force
  • 2020 - Facuty, Transseptal Training Course, STS Annual Meeting 2020
  • 2020 - CRT Meeting Abstract Reviewer
  • 2019 - AATS-Abstract Review Annual Meeting, Adult Cardiac-Aortic and Pulmonary Valve
  • 2019 - Associate Director - Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
  • 2019 - NIH Bioengineering, Technology, Surgical Sciences – Study Section Ad hoc Reviewer
  • 2019 - NY Society of Thoracic Surgeons, Secretary
  • 2019 - Course Instructor, Faculty, Transseptal Training Course, AATS 2019
  • 2019 - STS University-“Essentials of TAVR” Course Co-Director
  • 2018 - Associate Director - Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
  • 2018 - CRT Abstract Grading Committee
  • 2018 - New York Society of Thoracic Surgeons – Program Chair
  • 2018 - New York Society of Thoracic Surgeons – Annual Program Committee Member
  • 2018 - Course, Instructor, Faculty, Transseptal Training Course, AATS 2018
  • 2018 - AATS Biology Club
  • 2017 - Associate Director - Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
  • 2017 - European Association of Cardiothoracic Surgery Member
  • 2017 - THV Training Course Lecturer – Transcatheter Mitral Valve-in-Valve Replacement, Edwards Lifesciences
  • 2016 - TCTMD Mitral Newsletter Editor
  • 2016 - ACC Rating Panel-Treatment of Patients with Severe Aortic Stenosis Appropriate Use Criteria
  • 2016 - Associate Director - Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
  • 2016 - Member, American Association of Thoracic Surgery
  • 2015 - Cardiovascular Research Foundation CEC-DMC Committee
  • 2015 - Valve in Valve Coronary Obstruction Working Group-International Data Registry
  • 2015 - Associate Director - Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
  • 2015 - Faculty, Transcatheter Valvular Therapy (TVT) Annual Meeting
  • 2014 - Fellow, American College of Surgeons
  • 2014 - Fellow, American College of Cardiology
  • 2013 - Member, International Society of Heart and Lung Transplantation
  • 2012 - Member, American Heart Association Cardiovascular Surgery and Anesthesia Council
  • 2012 - Member, Society of Thoracic Surgeons
  • 2012 - Faculty, Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
  • 2010-2014 Fellow-in-Training, American College of Cardiology (ACC), Surgeons Council
  • 2005-2006 American Society of Artificial Internal Organs
  • 2004 - Student Member, American Heart Association
  • 1997-2001 Member, American Medical Association

Board Certifications

  • Cardiothoracic Surgery
  • Surgery

Honors & Awards

  • 2019: American Association of Thoracic Surgeons Biology Cup Winner - Best Presentation
  • 2017: Columbia University Deparment of Surgery - Junior Faculty Research Grant
  • 2016: American Association of Thoracic Surgeons Graham Surgical Investigator Award
  • 2015: Columbia University Department of Surgery - Kenneth Forde Research Award
  • 2008: Blakemore Prize – Best Resident Research Award, Columbia University College of Physicians and Surgeons
  • 2007: Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons
  • 2006: Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons
  • 2004: New Era Cardiac Surgery Conference Scholarship
  • 1995: Pi Tau Sigma, Mechanical Engineering Honor Society


Research Interests

  • Aortic aneurysm formation
  • Cardiomyopathy
  • Clinical outcomes after valve and hybrid surgery.
  • Regulation of myostatin signaling in human cardiomyopathy
  • Surgical and transcatheter valve replacement
  • TGFB regulation in non-syndromic aortic aneurysm formation.
  • Valve interstitial cell activation mechanisms after surgical and transcatheter valve replacement.

Selected Publications

  1. Nazif TM, Cahill TJ, Daniels D, McCabe J, Reisman M, Chakravarty T, Makkar R, Krishnaswamy A, Kapadia S, Chehab B, Wang J, Spies C, Rodriguez E, Hahn RT, Leon MB, George I. Real-World Experience with the Sapien 3 Ultra transcatheter heart valve: a propensity matched analysis from the United States. (submitted)
  2. Brener MI, Old A, Nemeth S, Kurlansky P, Nazif TM, Vahl TP, Khalique O, Hamid NB, Patel A, Ng V, Chen S, Cahill TJ, Rahim HM, Hahn RT, Bapat V, Ahmed MI, Leon MB, Kodali S, Eudailey KW, George I. Suprasternal Versus Transfemoral Access for Transcatheter Aortic Valve Replacement: Insights from a Propensity Score Matched Analysis. (submitted)
  3. Shahim B, Redfors B, Chen S, Dahlen T, Lindman B, Nazif T, Kapadia S, Gertz Z, Crawly A, Li D, Thourani V, Kodali S, Zajarias A, Babaliaros V, Guyton R, Elmariah S, Herrmann H, Mack M, Smith CR, Leon MB, George I. Prognostic Value of Serial Neutrophil-to-Lymphocyte Ratio in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement-The PARTNER I-II Trials and Registries. (submitted)
  4. Castillero E, Howsmon B, Rego BV, Keeney S, Driesbaugh KH, Xue Y, Camillo C, George I, Gorman RC, Gorman JH, Sacks MS, Levy RJ, Ferrari G. Altered Responsiveness to Transforming Growth Factor/Bone Morphogenic Protein Signaling and Increased CD45% Fibrocyte Presence in Mitral Valves are Distinctive of Ischemic Mitral Regurgitation After Myocardial Infarction. (submitted)
  5. Shahim B, Malasrie C, George I, Thourani VH, Biviano AB, Russo M, Brown DL, Babaliaros V, Guyton RA, Kodali SK, Nazif TM, McCabe JM, Williams M, Genereux P, Lu M, Yu X, Alu M, Webb JG, Mack MJ, Leon MB, Kosmidou I. Impact of Preexisting Atrial Fibrillation on Clinical Outcomes After Transcatheter or Surgical Aortic Valve Replacement for Severe Aortic Stenosis: an Analysis from the PARTNER 3 Trial. (submitted)
  6. Sadri S, Loeb GJ, Grinspoon A, Elvezio C, Sun SH, Ng VG, Khalique O, Moses JW, Patel AJ, George I, Hahn RT, Nazif TM, Leon MB, Kirtane AJ, Kodali SK, Feiner SK, Vahl TP. Towards a Virtual Future: Augmented Reality Guidance for Cerebral Embolic Protection during TAVR. (submitted)
  7. Yamabe T, Pearsall CA, Zhao Y, Kurlansky P, Bethancourt CN, Nitta S, George I, Smith CR, Takayama H. Incidence, Cause, and Outcome of Reintervention after Aortic Root Replacement. (submitted)
  8. Fam NP, von Bardeleban RS, Hensy M, Kodali SK, Smith RL, Hausleiter J, Ong G, Boone R, Ruf T, George I, Szerlip M, Nabauer M, Ali FM, Moss R, Bapat V, Schnitzler K, Kriedel F, Ye J, Deva DP, Mack MJ, Grayburn PA, Peterson MD, Leon MB, Hahn RT, Webb JG. Transfemoral Transcathetere Tricuspid Valve Replacement with the EVOQUE System for Severe Tricuspid Regurgitation: A Multicenter, Observational, First-in-Human Experience. (Accepted-JACC Cardiovasc Int)
  9. Von Ballmoos MC, Forrest JK, Williams MR, Mangi AA, Kleiman N, Yakubov SJ, Watson D, Kodali S, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Oh JK, Qiao H, Reardon MJ. Three-Year Outcomes with a Contemporary Self-Expanding Transcatheter Valve from the Evolut PRO US Clinical Sudy. (submitted)
  10. Yamabe T, Zhao Y, Kurlansky PA, Nitta S, Kelebeyev S, Bethancourt CN, George I, Smith CR, Takayama H. Chronic Kidney Disease stratifies short- and long-term outcomes after aortic root surgery. (submitted)
  11. Dallan, LA, Forrest JK, Reardon MJ, Szeto WY, George I, Kodali S, Kleiman NS, Yakubo SJ, Grubb KJ, Liu F, Baeza C, Attizzani GF. Transcatheter Aortic Valve Replacement with Self-Expandable Supra-Annular Valves for Failed Surgical Bioprostheses: Insights From TVT-Registry. (submitted)
  12. Gupta A, Mori M, Wang Y, Vahl T, Nazif T, Kirtane AJ, George I, Kodali S, Giersson A, Leon MB, Krumholz HM. Sex- and Race-based differences in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States, 2012-2017. (submitted)