Steven O. Marx, MD

Board Certifications: 
Clinical Cardiac Electrophysiology, Cardiovascular Disease
Profile Headshot

Overview

Areas of Expertise / Conditions Treated

Clinical Cardiac Electrophysiology, Outcomes Research, Resident Education, Clinical Research Trials, Cardiac Electrophysiology

Academic Appointments

  • Professor of Medicine (in Pharmacology)

Steven O. Marx, M.D., is the Director of the Cardiovascular Fellowship Program at Columbia University Medical Center/NewYork-Presbyterian Hospital and is director of the cardiology component of a NIH training grant for cardiology fellows and surgery residents.

His research program in cardiovascular diseases at Columbia has been focused in two major areas: molecular cardiology, particularly the regulation of ion channels in normal and pathological conditions in the heart, and vascular biology, particularly the molecular mechanisms of vascular smooth muscle proliferation, migration and contractility. Working with others at Columbia, Dr. Marx has identified rapamycin (sirolimus) as a therapeutic agent for preventing restenosis after angioplasty/stent implantation. He also characterized the dysfunction of the ryanodine receptor in heart failure. A major focus of Dr. Marx's current research is the regulation of arterial contractility and blood pressure by the ion channels.

Dr. Marx received his B.S. in Biology from Union College and M.D. from Albany Medical College as part of a six-year program. Following a one-year postdoctoral fellowship in ion channel research at Johns Hopkins, he completed an internship and residency at the University of Rochester-Strong Memorial Hospital followed by a Cardiology Fellowship and a Clinical Electrophysiology Fellowship at Mount Sinai Medical Center. He is board certified in Internal Medicine, Cardiology and Clinical Cardiac Electrophysiology. He is also the principal investigator of several NIH R01 grants and a T32 grant. Dr. Marx has served on NIH and AHA peer review committees, is a member of the AHA Founders Affiliate Research Committee, and serves on the New York Academy of Medicine Glorney-Raisbeck Selection Committee.

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Gender

  • Male

Location(s)

CUMC/Presbyterian Hospital and Vanderbilt Clinic
622 West 168th Street
New York, NY 10032
Primary

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • NYP Employee Plan
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Access (Exchange)
  • EPO
  • Gatekeeper (Exchange)
  • HMO
  • Medicare Managed Care
  • Pathway (Exchange)
  • POS
  • PPO

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Medicare

  • Traditional Medicare (NY)

Multiplan

  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO
  • The Empire Plan (NYSHIP)

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • Albany Medical College-Union University, NY
  • Internship: Strong Memorial Hospital, NY
  • Residency: Strong Memorial Hospital, NY
  • Fellowship: Mount Sinai Hospital - MD

Board Certifications

  • Clinical Cardiac Electrophysiology
  • Cardiovascular Disease

Honors & Awards

  • 1982 Westinghouse Science Talent Search Semi-Finalist
  • 1986 Magna Cum Laude, Biology/Sociology
  • 1988 Alpha Omega Alpha (AOA)
  • 1994-1995 American College of Cardiology/Merck Fellow
  • 1995 American College of Cardiology, NYS Chapter Young Investigator Award
  • 1995 Astra-Merck Young Investigator's Forum Second Prize in Basic Research
  • 1994-1995 John C. Sable Memorial Heart Fund Research Award
  • 1995 The Denber Prize for Research, Mount Sinai Cardiovascular Institute
  • 1996 Katz Award Finalist, American Heart Association
  • 1996-1997 Glorney-Raisbeck Fellowship of the NY Academy of Medicine
  • 1996-2001 Clinician-Scientist Award, American Heart Association

Research

The Marx laboratory studies the regulation of ion channels by macromolecular complexes. We have demonstrated that specific sequences within the ion channel (leucine zippers) recruit regulatory proteins, which modulate the ion channel function in normal and pathologic conditions. The laboratory is now focused on understanding the molecular components and functional implications of macromolecular complex formation of the large conductance calcium-activated potassium channel (BKCa, maxi-K) and the L-type voltage gated calcium channel. The laboratory utilizes both molecular biologic and electrophysiologic (planar lipid bilayer, patch clamp) techniques to elucidate these fundamental processes and emphasizes the links between these fundamental molecular processes and systems function. To date our work has had significant impact in understanding the triggers of fatal cardiac arrhythmias and mechanical dysfunction in heart failure. Present experiments are very likely to impact our understanding of control of peripheral blood pressure by the sympathetic nervous system.

Research Interests

  • Molecular biology/macromolecular complex formation of ion channels

Grants

PHOSPHORYLATION-DEPENDENT REGULATION OF CALCIUM CHANNELS BY MACROMOLECULAR COMPLEXES (Federal Gov)

Jul 1 2019 - May 31 2023

L-TYPE CHANNEL TRAFFICKING AND MODULATION IN HEART (Federal Gov)

Jul 15 2018 - Apr 30 2022

SIGNALING PATHWAYS AND REGULATORS OF CALCIUM CHANNELS IN HEART (Federal Gov)

Dec 20 2018 - Dec 19 2021

EXPLORING THE MOLECULAR PHYSIOLOGY OF ATRIAL FIBRILLATION (Federal Gov)

Dec 1 2017 - Nov 30 2021

ELUCIDATING THE MECHANISMS OF VASCULAR DYSFUNCTION IN HEART FAILURE (Federal Gov)

Jan 1 2016 - Dec 31 2019

CLINICAL & BASIC SCIENCE STUDIES IN LONG QT SYNDROME TYPE 3 (LQT3) (Federal Gov)

Aug 1 2014 - Jun 29 2019

CALMODULIN REGULATION OF NA+ CHANNELS IN NEURONS AND CARDIOMYOCYTES (Federal Gov)

Nov 1 2016 - Oct 31 2018

INVESTIGATION OF CALCIUM CHANNEL MODULATION IN CARDIOMYOCYTES BY NOVEL METHODS (Federal Gov)

Jun 1 2013 - May 31 2018

RYR1 MYOPATHY DATABASE (Private)

May 26 2017 - May 5 2018

EXPLORING MOLECULAR MECHANISMS OF ATRIAL FIBRILATION (Private)

Jul 1 2015 - Jun 30 2017

CALMODULIN REGULATION OF NA+ CHANNELS IN NEURONS AND CARDIOMYOCYTES (Federal Gov)

Nov 15 2014 - Jul 31 2016

ENHANCED PERSISTENT SODIUM CURRENT AND ITS ROLE IN DILATED CARDIOMYOPATHY (Private)

May 1 2014 - Apr 30 2016

BK CHANNEL MODULATION BY BETA SUBUNITS (Federal Gov)

Apr 1 2006 - Jan 31 2016

TARGETING SIGNALING PATHWAYS THAT REGULATE CAV1.2 FUNCTION FOR TREATING ARRHYTHMIAS (Private)

Jan 1 2013 - Dec 31 2015

IMPACT OF HIGH DEDUCTIBLE HEALTH PLANS ON HEALTH DISPARITIES FOR PATIENTS WITH CONGESTIVE HEART FAILURE (Private)

Jul 1 2014 - Jun 30 2015

CYTOPLASMIC INTERATIONS OF BK ALPHA AND BETA1 (Private)

Jul 1 2009 - Jun 30 2013

ALLOSTERIC MODULATION OF CARDIOVASCULAR ION CHANNELS (Federal Gov)

Sep 1 2007 - Apr 30 2013

IN-HOSPITAL PREDICTORS OF PRIMARY AND SECONDARY NON-ADHERENC IN POST-ACS PATIENTS: DEVELOPMENT AND VALIDATION OF A PREFI (Private)

Jul 1 2011 - Jun 30 2012

VALVULOATERIAL IMPEDANCE, ISOVOLUMIC PRESSURE VOLUME AREA, A ND FRAILTY AS PREDICTORS OF FUNCTIONAL AND CLINICAL IMPROVEM (Private)

Jul 1 2011 - Jun 30 2012

RESEARCH TRAINING FELLOWSHIPS FOR MEDICAL STU (Private)

Jul 1 2010 - Jun 30 2012

ION CHANNEL REGULATION BY MACROMOLECULAR COMPLEXES (Federal Gov)

Sep 1 2001 - Apr 30 2012

ROLE OF THE INLAMMATORY RESPONSE TO RADIOFREQUENCY ABLATION OF ATRIAL FIBRILLATION IN DETERMINING ABLATION EFFICACY (Private)

Jul 1 2009 - Jun 30 2010

ION CHANNELS AS NOVEL THERAPEUTIC TARGETS FOR ASTHMA (Private)

Jul 1 2007 - Jun 30 2010

ALTERED PHOSPHORYLATION OF CAV1/2 CHANNEL LINKED TO HEART FA ILURE AND HYPERTROPHY (Private)

Jul 1 2008 - Jul 1 2009

ROTTLERIN AND VASOREACTIVITY IN THE VASCULAR SMOOTH MUSCLE B K CHANNEL (Private)

Jul 1 2008 - Aug 31 2008

DAVID HAACK AWARD FROM YOUNG INVESTIGATORS FORUM (Private)

Nov 14 2002 - Nov 13 2005