Isaac George, MD
On the web
Overview
Isaac George, MD, joined Columbia University Medical Center/NewYork-Presbyterian in 2001 as a resident in general surgery after graduating from Duke University School of Medicine. He received a B.S. in Mechanical Engineering from the Massachusetts Institute of Technology in 1997. He completed a fellowship in cardiothoracic surgery in 2011 and a fellowship in interventional cardiology in 2012. He is a Professor of Surgery and Medicine, the Surgical Director of Structural Heart Disease at NewYork-Presbyterian Hospital, the Surgical Director of the Structural Heart and Valve Center, and Co-Director of the Mitral and Tricuspid Center.
Dr. George is board certified in thoracic (cardiac) surgery. His practice includes all types of open and reoperative adult cardiac surgery, including aortic, mitral, and tricuspid valve surgery, aortic aneurysm repair, coronary bypass grafting, and robotic surgery. He specializes in minimally invasive mitral valve repair. He performs 150 to 200 open heart surgeries each year and is the highest-volume heart surgeon in New York State. His annual surgical mortality rate is approximately 1.5%.
Dr. George is trained in both cardiac surgery and interventional cardiology. His practice includes transcatheter aortic valve replacement (TAVR), transcatheter mitral valve repair (MitraClip), transcatheter mitral and tricuspid valve replacement, and surgical TAVR explantation. He performs around 800 transcatheter procedures each year and has performed nearly 8,000 TAVR procedures.
He is a Primary Investigator for multiple national surgical and transcatheter trials and is involved in research related to aortic stenosis, aortic insufficiency, bicuspid aortic valves, mitral regurgitation, tricuspid regurgitation, and heart failure. His research includes both clinical and benchtop studies with translational applications.
Dr. George can be contacted directly at ig2006@cumc.columbia.edu
Watch: Meet Cardiothoracic Surgeon, Dr. Isaac George
Watch: Dr. Isaac George Discusses Advancements in Heart Valve Surgery
Watch: Dr. George talks Minimally Invasive Mitral Valve Surgery
Watch: Decision Making in Aortic Valve Disease with Dr. Isaac George
Watch: Dr. George Discusses Stroke Risk and TAVR
Watch: Dr. George Interviewed on the Doctors Podcast
Watch: Dr. George discuses his personal recovery from COVID
Watch: Dr. George Discusses the Foldex Polymer Valve
Read: Dr. George Explains Link Between Microplastics and Heart Disease
Read: Dr. George Talks Hybrid Cardiac Surgery: A Viable Strategy for Select Patients
Read: What To Expect After A Coronary Artery Bypass, According To Dr. George
Read: Dr. George Participates in World's First Use of Medical Device to Protect From Stroke During TAVR
Read: Dr. George On Expanded Transcatheter Options for Cardiac Patients
Read: Dr. George on Innovations in Hybrid Surgery
Read: Strategy and Decision Making for Patients with Aortic Stenosis
Read: Dr. George discusses SAVR vs TAVR for Aortic Stenosis
Dr. George hosts Taking it to Heart, the Columbia Heart Valve team's podcast. In each episode, Dr. George and the Columbia Heart Valve team discuss a new topic related to valvuar disease.
Click here for a full list and description of ongoing trials from Dr. George.
Click here for a complete list of publications from Dr. George.
Disclosures:
Grant Support: Medtronic, Boston Scientific, Edwards Lifesciences
Consultant (honoraria) – Zimmer Biomet, Atricure, Neosurgery, Neptune Medical, Abbvie, Johnson & Johnson, Durvena, Boston Scientific, Edwards Lifesciences, Medtronic, Encompass Medical, Summus Medical, Abbott SJM, BCI, Xeltis, Innocardiac, KIS Medical
Advisory Boards: Edwards Surgical, Medtronic Surgical, Medtronic Structural Mitral & Tricuspid, Trisol Medical, Valcare Medical, Durvena, Abbvie, Johnson & Johnson, Foldax Medical, Zimmer Biomet, Neosurgery, Abbvie, Boston Scientific, Summus Medical, BCI, Encompass Medical, HVT Medical, Innocardiac, KIS Medical, Retex Medical
Equity: Valcare Medical, Durvena, CardioMech, Vdyne, MitreMedical, BCI, Trisol Medical, HVT Medical, Foldax, KIS Medical
Institutional funding to Columbia University: Edwards Lifesciences, Medtronic, Abbott Vascular, Boston Scientific, JenaValve.
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- Aortic and Mitral Valve Surgery
- Aortic Aneurysm
- Aortic Aneurysm Repair
- Aortic Aneurysm Surgery
- Aortic Aneurysm With Dissection
- Aortic Arch Surgery
- Aortic Disease
- Aortic Dissection
- Aortic Stenosis
- Aortic Stent Grafts
- Aortic Surgery
- Aortic Valve Surgery
- Atrial Fibrillation, Surgical Treatment
- Bloodless Surgery
- Coronary Artery and Valvular Disease
- Coronary Artery Bypass Surgery (Off Pump)
- Heart Disease
- Heart Disease and Women
- Heart Failure
- Heart Surgery
- Heart Transplantation
- Heart Valve Disease
- Heart Valve Repair
- Heart Valve Replacement
- Heart Valve Surgery
- High Risk Surgery of the Elderly
- Minimally Invasive Aneurysm Repair
- Minimally Invasive Heart Surgery
- Minimally Invasive Valve Repair
- Mitral/Aortic Valve Replacement
- Mitral Valve Reconstruction
- Mitral Valve Repair
- Mitral Valve Replacement/Repair
- Mitral Valve Surgery
- Off Pump Coronary Bypass Surgery
- Open Heart Surgery
- Percutaneous Valve Interventions
- Pericardial Disease
- Robotic Surgery
- TAVR (Transcatheter Aortic Valve Replacement)
- Thoracic Aneurysm Repair
- Valve Reconstruction/Repair
- Valve Replacement
- Valvular Heart Disease
Academic Appointments
- Professor of Surgery (in Medicine) at the Columbia University Medical Center
Administrative Titles
- Surgical Director, Structural Heart and Valve Center
- Surgical Director, Structural Heart Disease at NewYork-Presbyterian Hospital
- Co-Director, Mitral and Tricuspid Center
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
- NewYork-Presbyterian Allen Hospital
- NewYork-Presbyterian Westchester
Gender
- Male
Schedule an Appointment
Virtual Visits/Telehealth
Virtual Visits allow you to connect with your provider from the comfort, convenience, and safety of your own home.
Phone Appointments
Connect Patient Portal
For existing patients, login to make an appointment, view documentation or contact your care provider.
Location(s)
Insurance Accepted
Affinity Health Plan
- Essential Plan
- Medicaid Managed Care
Amerigroup of New Jersey
- Medicaid Managed Care
AmeriHealth of New Jersey
- EPO - New Jersey Services
- HMO - New Jersey Services
- POS - New Jersey Services
- PPO - New Jersey Services
Amida Care
- Special Needs
Cigna
- EPO
- Great West (National)
- HMO
- Medicare Managed Care
- POS
- PPO
Emblem/GHI
- Medicare Managed Care
- PPO
Emblem/HIP
- ConnectiCare
- EPO
- Essential Plan
- HMO
- Medicaid Managed Care
- Medicare Managed Care
- POS
- PPO
- Select Care (Exchange)
- Vytra
Empire Blue Cross/Blue Shield
- EPO
- HMO
- Medicare Managed Care
- PPO
Empire Blue Cross Blue Shield HealthPlus
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
Fidelis Care
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
Healthfirst
- Child/Family Health Plus
- Leaf (Exchange)
- Medicaid Managed Care
- Medicare Managed Care
Horizon Blue Cross Blue Shield
- EPO - New Jersey Services
- HMO - New Jersey Services
- New Jersey Services (Medicaid Managed Care)
- POS - New Jersey Services
- PPO - New Jersey Services
Local 1199
- Local 1199
MagnaCare (National)
- MagnaCare
Medicare
- Railroad
- Traditional Medicare
Multiplan
- Multiplan
MVP Health Care
- Child/Family Health Plus
- Essential Plan
- HMO
- Medicaid Managed Care
QualCare
- HMO - New Jersey Services
- POS - New Jersey Services
- PPO - New Jersey Services
RiverSpring
- Special Needs
TRICARE
- TRICARE
UnitedHealthcare
- Compass (Exchange)
- Empire Plan
- HMO
- Medicaid (Community Plan)
- Medicare Managed Care
- Oxford Freedom
- Oxford HMO
- Oxford Liberty
- POS
- PPO
WellCare
- Medicaid Managed Care
- New Jersey Services (Medicare Managed Care)
World Trade Center Health Plan
- World Trade Center Health Plan
Credentials & Experience
Education & Training
- Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
Committees, Societies, Councils
- 2021: CRT- Abstract Reviewer, Annual Meeting
- 2021: AATS-Abstract Reviewer, Annual Meeting, Adult Cardiac
- 2020: 21st Century Cardiothoracic Surgical Society, Member
- 2020: ACC 2021 – Abstract Reviewer-Interventional and Structural: Non-Aortic Structural Heart Disease
- 2020: ACC 2021: Session Co-Chair – Contemporary Aortic Valve Disease Management
- 2020: NY Society of Thoracic Surgeons, Secretary, Program Committee
- 2020: TCT Challenging Case Abstract Reviewer
- 2020: AHA Cardiovascular Surgery and Anesthesia Council Leadership Committee
- 2020: AATS Cardiac Education Committee
- 2020: Scientific Sessions, American Heart Association Annual Meeting Abstract Reviewer
- 2020: EACTS – Annual Meeting Abstract reviewer
- 2020: STS COVID-19 Task Force
- 2020: Facuty, Transseptal Training Course, STS Annual Meeting 2020
- 2020: CRT Meeting Abstract Reviewer
- 2019: AATS-Abstract Review Annual Meeting, Adult Cardiac-Aortic and Pulmonary Valve
- 2019: Associate Director: Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
- 2019: NIH Bioengineering, Technology, Surgical Sciences – Study Section Ad hoc Reviewer
- 2019: NY Society of Thoracic Surgeons, Secretary
- 2019: Course Instructor, Faculty, Transseptal Training Course, AATS 2019
- 2019: STS University-“Essentials of TAVR” Course Co-Director
- 2018: Associate Director: Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
- 2018: CRT Abstract Grading Committee
- 2018: New York Society of Thoracic Surgeons – Program Chair
- 2018: New York Society of Thoracic Surgeons – Annual Program Committee Member
- 2018: Course, Instructor, Faculty, Transseptal Training Course, AATS 2018
- 2018: AATS Biology Club
- 2017: Associate Director: Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
- 2017: European Association of Cardiothoracic Surgery Member
- 2017: THV Training Course Lecturer – Transcatheter Mitral Valve-in-Valve Replacement, Edwards Lifesciences
- 2016: TCTMD Mitral Newsletter Editor
- 2016: ACC Rating Panel-Treatment of Patients with Severe Aortic Stenosis Appropriate Use Criteria
- 2016: Associate Director: Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
- 2016: Member, American Association of Thoracic Surgery
- 2015: Cardiovascular Research Foundation CEC-DMC Committee
- 2015: Valve in Valve Coronary Obstruction Working Group-International Data Registry
- 2015: Associate Director: Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
- 2015: Faculty, Transcatheter Valvular Therapy (TVT) Annual Meeting
- 2014: Fellow, American College of Surgeons
- 2014: Fellow, American College of Cardiology
- 2013: Member, International Society of Heart and Lung Transplantation
- 2012: Member, American Heart Association Cardiovascular Surgery and Anesthesia Council
- 2012: Member, Society of Thoracic Surgeons
- 2012: Faculty, Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting
- 2010 - 2014: Fellow-in-Training, American College of Cardiology (ACC), Surgeons Council
- 2005 - 2006: American Society of Artificial Internal Organs
- 2004: Student Member, American Heart Association
- 1997 - 2001: Member, American Medical Association
Board Certifications
- Cardiothoracic Surgery
- Surgery
Honors & Awards
- 2019: American Association of Thoracic Surgeons Biology Cup Winner - Best Presentation
- 2017: Columbia University Deparment of Surgery - Junior Faculty Research Grant
- 2016: American Association of Thoracic Surgeons Graham Surgical Investigator Award
- 2015: Columbia University Department of Surgery - Kenneth Forde Research Award
- 2008: Blakemore Prize – Best Resident Research Award, Columbia University College of Physicians and Surgeons
- 2007: Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons
- 2006: Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons
- 2004: New Era Cardiac Surgery Conference Scholarship
- 1995: Pi Tau Sigma, Mechanical Engineering Honor Society
Research
Director, Cardiac Surgery Research Lab
Research Interests
- Aortic aneurysm formation
- Cardiomyopathy
- Clinical outcomes after valve and hybrid surgery.
- Regulation of myostatin signaling in human cardiomyopathy
- Surgical and transcatheter valve replacement
- TGFB regulation in non-syndromic aortic aneurysm formation.
- Valve interstitial cell activation mechanisms after surgical and transcatheter valve replacement.
Selected Publications
- Nazif TM, Cahill TJ, Daniels D, McCabe J, Reisman M, Chakravarty T, Makkar R, Krishnaswamy A, Kapadia S, Chehab B, Wang J, Spies C, Rodriguez E, Hahn RT, Leon MB, George I. Real-World Experience with the Sapien 3 Ultra transcatheter heart valve: a propensity matched analysis from the United States. (submitted)
- Brener MI, Old A, Nemeth S, Kurlansky P, Nazif TM, Vahl TP, Khalique O, Hamid NB, Patel A, Ng V, Chen S, Cahill TJ, Rahim HM, Hahn RT, Bapat V, Ahmed MI, Leon MB, Kodali S, Eudailey KW, George I. Suprasternal Versus Transfemoral Access for Transcatheter Aortic Valve Replacement: Insights from a Propensity Score Matched Analysis. (submitted)
- Shahim B, Redfors B, Chen S, Dahlen T, Lindman B, Nazif T, Kapadia S, Gertz Z, Crawly A, Li D, Thourani V, Kodali S, Zajarias A, Babaliaros V, Guyton R, Elmariah S, Herrmann H, Mack M, Smith CR, Leon MB, George I. Prognostic Value of Serial Neutrophil-to-Lymphocyte Ratio in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement-The PARTNER I-II Trials and Registries. (submitted)
- Castillero E, Howsmon B, Rego BV, Keeney S, Driesbaugh KH, Xue Y, Camillo C, George I, Gorman RC, Gorman JH, Sacks MS, Levy RJ, Ferrari G. Altered Responsiveness to Transforming Growth Factor/Bone Morphogenic Protein Signaling and Increased CD45% Fibrocyte Presence in Mitral Valves are Distinctive of Ischemic Mitral Regurgitation After Myocardial Infarction. (submitted)
- Shahim B, Malasrie C, George I, Thourani VH, Biviano AB, Russo M, Brown DL, Babaliaros V, Guyton RA, Kodali SK, Nazif TM, McCabe JM, Williams M, Genereux P, Lu M, Yu X, Alu M, Webb JG, Mack MJ, Leon MB, Kosmidou I. Impact of Preexisting Atrial Fibrillation on Clinical Outcomes After Transcatheter or Surgical Aortic Valve Replacement for Severe Aortic Stenosis: an Analysis from the PARTNER 3 Trial. (submitted)
- Sadri S, Loeb GJ, Grinspoon A, Elvezio C, Sun SH, Ng VG, Khalique O, Moses JW, Patel AJ, George I, Hahn RT, Nazif TM, Leon MB, Kirtane AJ, Kodali SK, Feiner SK, Vahl TP. Towards a Virtual Future: Augmented Reality Guidance for Cerebral Embolic Protection during TAVR. (submitted)
- Yamabe T, Pearsall CA, Zhao Y, Kurlansky P, Bethancourt CN, Nitta S, George I, Smith CR, Takayama H. Incidence, Cause, and Outcome of Reintervention after Aortic Root Replacement. (submitted)
- Fam NP, von Bardeleban RS, Hensy M, Kodali SK, Smith RL, Hausleiter J, Ong G, Boone R, Ruf T, George I, Szerlip M, Nabauer M, Ali FM, Moss R, Bapat V, Schnitzler K, Kriedel F, Ye J, Deva DP, Mack MJ, Grayburn PA, Peterson MD, Leon MB, Hahn RT, Webb JG. Transfemoral Transcathetere Tricuspid Valve Replacement with the EVOQUE System for Severe Tricuspid Regurgitation: A Multicenter, Observational, First-in-Human Experience. (Accepted-JACC Cardiovasc Int)
- Von Ballmoos MC, Forrest JK, Williams MR, Mangi AA, Kleiman N, Yakubov SJ, Watson D, Kodali S, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Oh JK, Qiao H, Reardon MJ. Three-Year Outcomes with a Contemporary Self-Expanding Transcatheter Valve from the Evolut PRO US Clinical Sudy. (submitted)
- Yamabe T, Zhao Y, Kurlansky PA, Nitta S, Kelebeyev S, Bethancourt CN, George I, Smith CR, Takayama H. Chronic Kidney Disease stratifies short- and long-term outcomes after aortic root surgery. (submitted)
- Dallan, LA, Forrest JK, Reardon MJ, Szeto WY, George I, Kodali S, Kleiman NS, Yakubo SJ, Grubb KJ, Liu F, Baeza C, Attizzani GF. Transcatheter Aortic Valve Replacement with Self-Expandable Supra-Annular Valves for Failed Surgical Bioprostheses: Insights From TVT-Registry. (submitted)
- Gupta A, Mori M, Wang Y, Vahl T, Nazif T, Kirtane AJ, George I, Kodali S, Giersson A, Leon MB, Krumholz HM. Sex- and Race-based differences in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States, 2012-2017. (submitted)
For a complete list of publications, please visit PubMed.gov