Clinical Trials

  • Principal Investigator:

    Marwah Abdalla, MD
    The Center for Behavioral Cardiovascular Health (CBCH) is conducting a research study to examine the relationship between sleep and nighttime blood pressure levels and whether this relationship has something to do with the way our nervous system functions. Qualified participants who complete a 2 day study that includes an overnight sleep assessment at the Columbia University Cardiopulmonary Sleep and Ventilation Disorders Center are eligible for a $200 compensation.
  • Principal Investigator:

    Tamim M. Nazif, MD
    This is a prospective, single-arm, observational, multicenter registry. The intent is to gather information on the commercially approved device, device SAPIEN 3 Ultra transcatheter heart valve (THV). This valve consists of a short metal tube (stent) that holds the valve in its intended position and has valve leaflets made of biological material derived from cows to direct the flow of blood through the heart the way a normal valve would if it was healthy. This artificial valve is delivered into the heart by a small flexible tube (catheter) that is about as big around as a pencil. This flexible...
  • Principal Investigator:

    Amardeep S. Saluja, MD
    The primary objective of the TactiFlex PAF IDE clinical trial is to demonstrate that ablation with the TactiFlex Ablation Catheter, Sensor-Enabled (TactiFlex SE), in conjunction with a compatible RF generator and three-dimensional mapping system, is safe and effective for the treatment of drug refractory, symptomatic paroxysmal atrial fibrillation (PAF) when following standard electrophysiology mapping and radiofrequency (RF) ablation procedures. The study is a prospective, non-randomized multi-center clinical investigation. The design includes a main study and a separate substudy. Subjects...
  • Principal Investigator:

    Nir Y. Uriel, MD
    The purpose of this research study is to understand if aspirin is needed in patients heart failure implanted with the HeartMate 3. Patients with devices like the HeartMate 3 take two blood thinner medicines, specifically warfarin and aspirin. Patients implanted with devices like the HeartMate 3 experience both clotting and bleeding complications. Data suggest the HeartMate 3 may not require as much anticoagulation (blood thinners) as are normally used. This study will test if patients need aspirin together with warfarin or just warfarin alone.
  • Principal Investigator:

    Daichi Shimbo, MD
    We are conducting a research study in adults to test whether blood pressure (BP) measured in a clinic setting without a technician present is comparable to blood pressure levels while awake outside of the clinic on an Ambulatory Blood Pressure Monitoring (ABPM) device. We will also test whether asleep blood pressure can be accurately determined using a home blood pressure monitoring device, called HBPM. Eligible participants include English or Spanish-speaking adults who don't have cardiovascular disease and are NOT currently taking a blood pressure lowering medication. Study participation...
  • Principal Investigator:

    Daichi Shimbo, MD
    We are conducting a research study in adults to test whether blood pressure (BP) measured in a clinic setting without a technician present is comparable to blood pressure levels while awake outside of the clinic on an Ambulatory Blood Pressure Monitoring (ABPM) device. We will also test whether asleep blood pressure can be accurately determined using a home blood pressure monitoring device, called HBPM. Eligible participants include English or Spanish-speaking adults who don't have cardiovascular disease and are NOT currently taking a blood pressure lowering medication. Study participation...
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    Assessing the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation associated with heart failure.
  • Principal Investigator:

    Gabriel Tal Sayer, MD
    This is a prospective, randomized, open-label, international, multi-center clinical study to evaluate thesafety and efficacy of the AccuCinch Ventricular Repair System in patients with heart failure and reduced ejection fraction (HFrEF).
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    This is a research study to evaluate the use of a device to treat patients with Heart Failure (HF) who have moderate aortic stenosis (AS). The Edwards SAPIEN 3 has already been approved by the FDA for use in patients who require an aortic valve replacement due to severe aortic stenosis. This is an international, multicenter, randomized, open-label, clinical trial comparing the safety and effectiveness of TAVR(Transcatheter Aortic Valve Replacement) with the Edwards SAPIEN 3 THV (transcatheter heart valve) and medical therapy to medical therapy alone in HF patients with moderate AS. You will...
  • Principal Investigator:

    Susheel Kumar Kodali, MD
    The goal is to evaluate the safety and effectiveness of the TriClip device in patients with severe Tricuspid Regurgitation (TR) and are deemed greater risk for mortality with tricuspid valve surgery.

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